GRK2(Phospho-Tyr86) Polyclonal Antibody
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Product information
| Price | €175, €275, €395 |
|---|---|
| Size | 20 µl/µg | 50 µl/µg | 100 µl/µg |
| Short name | GRK2 |
| Host | Rabbit |
| Isotype | IgG |
| Target protein | ADRBK1 |
| Recommended applications | IF, IHC-p, WB |
| Reactivity | Human, Mouse, Rat |
| Immunogen | Synthesized peptide derived from human GRK2 (Phospho-Tyr86) |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Formulation | Liquid in PBS containing 50% glycerol; 0.5% BSA and 0.02% sodium azide. |
| Storage | -20°C for 1 year |
| Product code | MB-AP12711 |
Additional information
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The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.
GRK2 ,Phospho-Tyr86, Beta-adrenergic receptor kinase 1, Beta-ARK-1, EC 2.7.11.15, G-protein coupled receptor kinase 2
Human: P25098
Human: 156