Stat6(Phospho Tyr641) Polyclonal Antibody
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Product information
| Price | €175, €275, €395 |
|---|---|
| Size | 20 µl/µg | 50 µl/µg | 100 µl/µg |
| Short name | Signal transducer and activator of transcription 6 |
| Host | Rabbit |
| Isotype | IgG |
| Target protein | STAT6 |
| Recommended applications | ELISA, IF, IHC-p, WB |
| Reactivity | Human, Mouse, Rat |
| Immunogen | The antiserum was produced against synthesized peptide derived from human STAT6 around the phosphorylation site of Tyr641. AA range:608-657 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Formulation | Liquid in PBS containing 50% glycerol; 0.5% BSA and 0.02% sodium azide. |
| Storage | -20°C for 1 year |
| Product code | MB-AP13304 |
Additional information
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The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors| STAT family members are phosphorylated by the receptor associated kinases| and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L)| which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells| expression of cell surface markers| and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.
Signal transducer and activator of transcription 6, STAT6, Signal transducer and activator of transcription 6, IL-4 Stat
Human: P42226, Mouse: P52633
Human: 6778, Mouse: 20852