Rhotekin Polyclonal Antibody
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Product information
| Price | €175, €275, €395 |
|---|---|
| Size | 20 µl/µg | 50 µl/µg | 100 µl/µg |
| Short name | Rhotekin Antibody |
| Host | Rabbit |
| Isotype | IgG |
| Target protein | RTKN |
| Recommended applications | ELISA, IHC-p |
| Reactivity | Human, Mouse, Rat |
| Immunogen | Synthesized peptide derived from Rhotekin . at AA range: 80-160 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Formulation | Liquid in PBS containing 50% glycerol; 0.5% BSA and 0.02% sodium azide. |
| Storage | -20°C for 1 year |
| Product code | MB-AP14348 |
Additional information
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RTKN (rhotekin) encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
RTKN, RTKN1, Rhotekin
Human: Q9BST9, Mouse: Q8C6B2, Rat: Q6V7V2
Human: 6242, Mouse: 20166, Rat: 297383