4E-BP1 Monoclonal Antibody
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Product information
| Price | €240, €410 |
|---|---|
| Size | 50 µl/µg | 100 µl/µg |
| Short name | Eukaryotic translation initiation factor 4E-binding protein 1 |
| Host | Mouse |
| Isotype | IgG |
| Target protein | EIF4EBP1 |
| Recommended applications | ELISA, IF, IHC-p, WB |
| Reactivity | Human |
| Immunogen | Purified recombinant fragment of 4E-BP1 expressed in E. Coli. |
| Purification | Affinity purification |
| Formulation | Purified antibody in PBS containing 0.03% sodium azide. |
| Storage | -20°C for 1 year |
| Product code | MB-AM10492 |
Additional information
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This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
EIF4EBP1, Eukaryotic translation initiation factor 4E-binding protein 1, 4E-BP1, eIF4E-binding protein 1, Phosphorylated heat- and acid-stable protein regulated by insulin 1, PHAS-I
Human: Q13541, Mouse: Q60876
Human: 1978