AIF-M1 Monoclonal Antibody

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Product information

Price

€240, €410

Size

50 µl/µg | 100 µl/µg

Short name

Apoptosis-inducing factor 1 mitochondrial

Host

Mouse

Isotype

IgG

Target protein

AIFM1

Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Purified recombinant fragment of human AIF-M1 expressed in E. Coli.

Purification

Affinity purification

Formulation

Ascitic fluid containing 0.03% sodium azide;0.5% BSA; 50%glycerol.

Storage

-20°C for 1 year

Product code

MB-AM10477

Additional information

This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome
AIFM1, AIF, PDCD8, Apoptosis-inducing factor 1, mitochondrial, Programmed cell death protein 8, ACTN3
Human: O95831, Mouse: Q9Z0X1, Rat: Q9JM53
Human: 9131, Mouse: 26926, Rat: 83533