Arrestin-Beta-1 Polyclonal Antibody
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Product information
| Price | €175, €275, €395 |
|---|---|
| Size | 20 µl/µg | 50 µl/µg | 100 µl/µg |
| Short name | Arrestin-beta-1 Antibody |
| Host | Rabbit |
| Isotype | IgG |
| Target protein | ARRB1 |
| Recommended applications | ELISA, IF, IHC-p, WB |
| Reactivity | Human, Monkey |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Arrestin 1. AA range:369-418 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Formulation | Liquid in PBS containing 50% glycerol; 0.5% BSA and 0.02% sodium azide. |
| Storage | -20°C for 1 year |
| Product code | MB-AP11722 |
Additional information
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Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.
ARRB1, ARR1, Beta-arrestin-1, Arrestin beta-1
Human: P49407, Mouse: Q8BWG8
Human: 408