Atm Polyclonal Antibody
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Product information
| Price | €175, €275, €395 |
|---|---|
| Size | 20 µl/µg | 50 µl/µg | 100 µl/µg |
| Short name | Atm Antibody |
| Host | Rabbit |
| Isotype | IgG |
| Target protein | ATM |
| Recommended applications | ELISA, IHC-p |
| Reactivity | Human |
| Immunogen | Synthesized peptide derived from Atm . at AA range: 1920-2000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Formulation | Liquid in PBS containing 50% glycerol; 0.5% BSA and 0.02% sodium azide. |
| Storage | -20°C for 1 year |
| Product code | MB-AP11677 |
Additional information
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The protein encoded by ATM belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
ATM, Serine-protein kinase ATM, Ataxia telangiectasia mutated, A-T mutated
Human: Q13315, Mouse: Q62388
Human: 472