Product information
Price | €240, €410 |
---|---|
Size | 50 µl/µg | 100 µl/µg |
Short name | B-cell lymphoma, leukemia 10 |
Host | Mouse |
Isotype | IgG |
Target protein | BCL10 |
Recommended applications | ELISA, FCM, ICC, IF, IHC-p, WB |
Reactivity | Human, Mouse |
Immunogen | Purified recombinant fragment of human Bcl-10 expressed in E. Coli. |
Purification | Affinity purification |
Formulation | Purified antibody in PBS containing 0.03% sodium azide. |
Storage | -20°C for 1 year |
Product code | MB-AM10449 |
Additional information
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This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants.
BCL10, CIPER, CLAP, B-cell lymphoma, leukemia 10, B-cell CLL, lymphoma 10, Bcl-10, CARD-containing molecule enhancing NF-kappa-B, CARD-like apoptotic protein, hCLAP, CED-3, ICH-1 prodomain homologous E10-like regulator, CIPER, Cellular homolog
Human: O95999, Mouse: Q9Z0H7
Human: 8915, Mouse: 12042