Bestrophin-1 Polyclonal Antibody
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Product information
| Price | €175, €275, €395 |
|---|---|
| Size | 20 µl/µg | 50 µl/µg | 100 µl/µg |
| Short name | Bestrophin-1 |
| Host | Rabbit |
| Isotype | IgG |
| Target protein | BEST1 |
| Recommended applications | IF, IHC-p, WB |
| Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic Peptide of Bestrophin-1 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Formulation | Liquid in PBS containing 50% glycerol; 0.5% BSA and 0.02% sodium azide. |
| Storage | -20°C for 1 year |
| Product code | MB-AP13061 |
Additional information
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This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.
Bestrophin-1 ,TU15B,Vitelliform macular dystrophy protein 2, Bestrophin-1, TU15B, Vitelliform macular dystrophy protein 2
Human: O76090, Mouse: O88870
Human: 7439