Caspase-1 Polyclonal Antibody
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Product information
| Price | €175, €275, €395 |
|---|---|
| Size | 20 µl/µg | 50 µl/µg | 100 µl/µg |
| Short name | Caspase-1 Antibody |
| Host | Rabbit |
| Isotype | IgG |
| Target protein | CASP1 |
| Recommended applications | ELISA, IF, IHC-p, WB |
| Reactivity | Human, Rat |
| Immunogen | The antiserum was produced against synthesized peptide derived from the C-terminal region of human CASP1. AA range:350-400 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Formulation | Liquid in PBS containing 50% glycerol; 0.5% BSA and 0.02% sodium azide. |
| Storage | -20°C for 1 year |
| Product code | MB-AP11471 |
Additional information
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CASP1 encodes a protein (caspase 1) which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
Human: P29466, Mouse: P29452, Rat: P43527
Human: 834, Mouse: 12362