Centriolin Polyclonal Antibody
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Product information
| Price | €175, €275, €395 |
|---|---|
| Size | 20 µl/µg | 50 µl/µg | 100 µl/µg |
| Short name | Centriolin Antibody |
| Host | Rabbit |
| Isotype | IgG |
| Target protein | CCP110 |
| Recommended applications | ELISA, IHC-p |
| Reactivity | Human |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CEP110. AA range:850-900 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Formulation | Liquid in PBS containing 50% glycerol; 0.5% BSA and 0.02% sodium azide. |
| Storage | -20°C for 1 year |
| Product code | MB-AP11285 |
Additional information
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Cytokinesis occurs during the late stages of mitosis and describes the process by which the cytoplasm of one cell is divided to create two subsequent daughter cells. Centriolin, also known as CEP110, is a coiled-coil centrosomal protein that is required for centrosome maturation and correct centrosome function. During abscission, the last step in cytokinesis, Centriolin both coordinates and grounds vesicle-fusion and vesicle-exocyst complexes to the midbody of the daughter cells. Acting as an anchor for the protein complexes needed to complete separation of the two cells, Centriolin initiates and controls vesicle-mediated cell cleavage. Through its ability to signal initiation of the last step of vertebrate cytokinesis, Centriolin regulates cell proliferation and contributes to proper entry into the S phase of mitosis.
CCP110, CEP110, CP110, KIAA0419, Centriolar coiled-coil protein of 110 kDa, Centrosomal protein of 110 kDa, CP110, Cep110
Human: O43303, Mouse: Q7TSH4
Human: 9738