Product information
Price | €240, €410 |
---|---|
Size | 50 µl/µg | 100 µl/µg |
Short name | Adapter molecule crk |
Host | Mouse |
Isotype | IgG |
Target protein | CRK |
Recommended applications | ELISA, FCM, ICC, IF, IHC-p, WB |
Reactivity | Human |
Immunogen | Purified recombinant fragment of human Crk II expressed in E. Coli. |
Purification | Affinity purification |
Formulation | Ascitic fluid containing 0.03% sodium azide;0.5% BSA; 50%glycerol. |
Storage | -20°C for 1 year |
Product code | MB-AM10355 |
Additional information
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This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
CRK, Adapter molecule crk, Proto-oncogene c-Crk, p38
Human: P46108, Mouse: Q64010
Human: 1398