Dbf4 Polyclonal Antibody

Categories: ,
Dbf4 Polyclonal Antibody
Order now

Prices are excluding VAT and shipping costs

Product information

Price

€175, €275, €395
Size

20 µl/µg | 50 µl/µg | 100 µl/µg
Short name

Dbf4 Antibody
Host

Rabbit
Isotype

IgG
Target protein

DBF4
Recommended applications

ELISA, IHC-p, WB
Reactivity

Human, Monkey, Mouse
Immunogen

The antiserum was produced against synthesized peptide derived from human DBF4. AA range:10-59
Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Formulation

Liquid in PBS containing 50% glycerol; 0.5% BSA and 0.02% sodium azide.
Storage

-20°C for 1 year
Product code

MB-AP10918

Additional information

Prev Next
The Dbf4/Cdc7 protein kinase is essential for the activation of replication origins during S phase. Cdc7-Dbf4 efficiently phosphorylates several proteins that are required for the initiation of DNA replication, including five of the six minichromosome maintenance (Mcm) proteins and the p180 subunit of DNA polymerase α-primase. This protein complex consists of the catalytic subunit Cdc7 associating with the regulatory and activating subunit Dbf4, and the kinase activity of the complex is regulated throughout the cell cycle mainly by fluctuating levels of Dbf4. Cdc7 is consistently expressed throughout the cell cycle, while the expression of Dbf4 is absent during G1 phase and accumulates during S and G2 phases. The anaphase-promoting complex rapidly degrades Dbf4 at the time of chromosome segregation, and the stability of Dbf4 remains low during pre-Start G1 phase. The coordinated degradation of Dbf4 and the time of chromosomes separation is important to ensuring that prereplicative complexes, which assemble after chromosome segregation, do not immediately refire.
DBF4, ASK, DBF4A, ZDBF1, Protein DBF4 homolog A, Activator of S phase kinase, Chiffon homolog A, DBF4-type zinc finger-containing protein 1
Human: Q9UBU7, Mouse: Q9QZ41
Human: 10926, Mouse: 27214