E2A Polyclonal Antibody
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Product information
| Price | €175, €275, €395 |
|---|---|
| Size | 20 µl/µg | 50 µl/µg | 100 µl/µg |
| Short name | E2A Antibody |
| Host | Rabbit |
| Isotype | IgG |
| Target protein | TCF3 |
| Recommended applications | ELISA, IHC-p |
| Reactivity | Human, Mouse, Rat |
| Immunogen | The antiserum was produced against synthesized peptide derived from human E2A. AA range:321-370 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Formulation | Liquid in PBS containing 50% glycerol; 0.5% BSA and 0.02% sodium azide. |
| Storage | -20°C for 1 year |
| Product code | MB-AP10818 |
Additional information
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TCF3 (transcription factor 3) encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of TCF3 or diminished activity of the encoded protein may play a role in lymphoid malignancies. TCF3 is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t (1; 19), with PBX1), childhood leukemia (t (19; 19), with TFPT) and acute leukemia (t (12; 19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for TCF3, and a pseudogene of TCF3 is located on the short arm of chromosome 9.
TCF3, BHLHB21, E2A, ITF1, Transcription factor E2-alpha, Class B basic helix-loop-helix protein 21, bHLHb21, Immunoglobulin enhancer-binding factor E12/E47, Immunoglobulin transcription factor 1, Kapp
Human: P15923, Mouse: P15806, Rat: P21677
Human: 6929, Mouse: 21423, Rat: 171046