Product information
Price | €175, €275, €395 |
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Size | 20 µl/µg | 50 µl/µg | 100 µl/µg |
Short name | Factor VIII Antibody |
Host | Rabbit |
Isotype | IgG |
Target protein | F8 |
Recommended applications | ELISA, IHC-p, WB |
Reactivity | Human, Mouse |
Immunogen | The antiserum was produced against synthesized peptide derived from human Factor VIII. AA range:2161-2210 |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Formulation | Liquid in PBS containing 50% glycerol; 0.5% BSA and 0.02% sodium azide. |
Storage | -20°C for 1 year |
Product code | MB-AP10685 |
Additional information
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F8 encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. F8 produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. DefectsF8 results in hemophilia A, a common recessive X-linked coagulation disorder.
F8, F8C, Coagulation factor VIII, Antihemophilic factor, AHF, Procoagulant component
Human: P00451, Mouse: Q06194
Human: 2157, Mouse: 14069