HER2(Phospho-Tyr1139) Polyclonal Antibody
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Product information
| Price | €175, €275, €395 |
|---|---|
| Size | 20 µl/µg | 50 µl/µg | 100 µl/µg |
| Short name | HER2 |
| Host | Rabbit |
| Isotype | IgG |
| Target protein | ERBB2 |
| Recommended applications | IF, IHC-p, WB |
| Reactivity | Human, Mouse, Rat |
| Immunogen | Synthesized peptide derived from human HER2 (Phospho-Tyr1139) |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Formulation | Liquid in PBS containing 50% glycerol; 0.5% BSA and 0.02% sodium azide. |
| Storage | -20°C for 1 year |
| Product code | MB-AP13458 |
Additional information
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This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However| it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer| stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways| such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported| with the most common allele| Ile654/Ile655| shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers| including breast and ovarian tumors. Alternative splicing results in several additional transcript variants| some encoding d
HER2 ,Phospho-Tyr1139, Receptor tyrosine-protein kinase erbB-2, EC 2.7.10.1, Metastatic lymph node gene 19 protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, CD antigen CD340
Human: P04626
Human: 2064