IDE Monoclonal Antibody(3H4)
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Product information
| Price | €175, €275, €395 |
|---|---|
| Size | 20 µl/µg | 50 µl/µg | 100 µl/µg |
| Short name | Insulin-degrading enzyme |
| Host | Mouse |
| Isotype | IgG |
| Target protein | IDE |
| Recommended applications | ICC, IF, IHC-p, WB |
| Reactivity | Human |
| Immunogen | Synthetic Peptide of IDE |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Formulation | PBS; pH 7.4; containing 0.5%BSA; 0.02% sodium azide as Preservative and 50% Glycerol. |
| Storage | -20°C for 1 year |
| Product code | MB-AM10517 |
Additional information
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This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been describe
IDE, Insulin-degrading enzyme, Abeta-degrading protease, Insulin protease, Insulinase, Insulysin
Human: P14735, Mouse: Q9JHR7, Rat: P35559
Human: 341625700