Product information
Price | €240, €410 |
---|---|
Size | 50 µl/µg | 100 µl/µg |
Short name | Interleukin-1 beta |
Host | Mouse |
Isotype | IgG |
Target protein | IL1B |
Recommended applications | ELISA, ICC, IF, IHC-p, WB |
Reactivity | Human |
Immunogen | Purified recombinant fragment of human IL-1Beta expressed in E. Coli. |
Purification | Affinity purification |
Formulation | Ascitic fluid containing 0.03% sodium azide;0.5% BSA; 50%glycerol. |
Storage | -20°C for 1 year |
Product code | MB-AM10234 |
Additional information
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The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
IL1B, IL1F2, Interleukin-1 beta, IL-1 beta, Catabolin
Human: P01584, Mouse: P10749
Human: 3553