Product information
Price | €175, €275, €395 |
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Size | 20 µl/µg | 50 µl/µg | 100 µl/µg |
Short name | KCNQ2/3/4/5 Antibody |
Host | Rabbit |
Isotype | IgG |
Target protein | KCNQ2 |
Recommended applications | ELISA, IHC-p |
Reactivity | Human, Mouse, Rat |
Immunogen | The antiserum was produced against synthesized peptide derived from human Kv7.3/KCNQ3. AA range:191-240 |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Formulation | Liquid in PBS containing 50% glycerol; 0.5% BSA and 0.02% sodium azide. |
Storage | -20°C for 1 year |
Product code | MB-AP10091 |
Additional information
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The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.
KCNQ2, Potassium voltage-gated channel subfamily KQT member 2, KQT-like 2, Neuroblastoma-specific potassium channel subunit alpha KvLQT2, Voltage-gated potassium channel subunit Kv7.2, KCNQ3, Potassiu
Human: O43526/O43525/P56696/Q9NR82, Rat: O88943/O88944/Q9JK96
Human: 3786, Mouse: 16536/110862/60613/226922, Rat: 170848/29682