Mi2- Alpha Monoclonal Antibody
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Product information
| Price | €240, €410 |
|---|---|
| Size | 50 µl/µg | 100 µl/µg |
| Short name | Chromodomain-helicase-DNA-binding protein 3 |
| Host | Mouse |
| Isotype | IgG |
| Target protein | CHD3 |
| Recommended applications | FCM, ICC, IF, IHC-p, WB |
| Reactivity | Bovine, Dog, Human, Mouse, Pig, Rat |
| Immunogen | Purified recombinant human Mi2-α (C-terminus) protein fragments expressed in E.coli. |
| Purification | Affinity purification |
| Formulation | Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4; 150 mM NaCl) with 0.2% sodium azide; 50% glycerol. |
| Storage | -20°C for 1 year |
| Product code | MB-AM10188 |
Additional information
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This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.
CHD3, Chromodomain-helicase-DNA-binding protein 3, CHD-3, ATP-dependent helicase CHD3, Mi-2 autoantigen 240 kDa protein, Mi2-alpha, Zinc finger helicase, hZFH
Human: Q12873
Human: 1107