MLL Monoclonal Antibody

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Product information

Price

€240, €410

Size

50 µl/µg | 100 µl/µg

Short name

Histone-lysine N-methyltransferase MLL

Host

Mouse

Isotype

IgG

Target protein

MLL

Reactivity

Human

Immunogen

Purified recombinant fragment of MLL (aa3751-3968) expressed in E. Coli.

Purification

Affinity purification

Formulation

Ascitic fluid containing 0.03% sodium azide;0.5% BSA; 50%glycerol.

Storage

-20°C for 1 year

Product code

MB-AM10185

Additional information

This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.
MLL, ALL1, CXXC7, HRX, HTRX, KMT2A, MLL1, TRX1, Histone-lysine N-methyltransferase MLL, ALL-1, CXXC-type zinc finger protein 7, Lysine N-methyltransferase 2A, KMT2A, Trithorax-like protein, Zinc finger protein HRX
Human: Q03164, Mouse: P55200
Human: 4297