Nibrin Polyclonal Antibody
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Product information
| Price | €175, €275, €395 |
|---|---|
| Size | 20 µl/µg | 50 µl/µg | 100 µl/µg |
| Short name | Nibrin Antibody |
| Host | Rabbit |
| Isotype | IgG |
| Target protein | NBN |
| Recommended applications | ELISA, IF, IHC-p, WB |
| Reactivity | Human |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Nibrin. AA range:251-300 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Formulation | Liquid in PBS containing 50% glycerol; 0.5% BSA and 0.02% sodium azide. |
| Storage | -20°C for 1 year |
| Product code | MB-AP14886 |
Additional information
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Mutations in NBN are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. Nibrin is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. NBN product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.
NBN, NBS, NBS1, P95, Nibrin, Cell cycle regulatory protein p95, Nijmegen breakage syndrome protein 1
Human: O60934, Mouse: Q9R207, Rat: Q9JIL9
Human: 4683, Mouse: 27354, Rat: 85482