NUB1 Polyclonal Antibody
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Product information
| Price | €175, €275, €395 |
|---|---|
| Size | 20 µl/µg | 50 µl/µg | 100 µl/µg |
| Short name | NUB1 Antibody |
| Host | Rabbit |
| Isotype | IgG |
| Target protein | NUB1 |
| Recommended applications | ELISA, IHC-p, WB |
| Reactivity | Human, Monkey, Mouse |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NYREN18. AA range:566-615 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Formulation | Liquid in PBS containing 50% glycerol; 0.5% BSA and 0.02% sodium azide. |
| Storage | -20°C for 1 year |
| Product code | MB-AP14830 |
Additional information
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NUB1 encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. Negative regulator of ubiquitin like proteins 1 encoded by NUB1 regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. Negative regulator of ubiquitin like proteins 1 interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with negative regulator of ubiquitin like proteins 1, which may contribute to the pathogenesis. Negative regulator of ubiquitin like proteins 1 is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of NUB1 results in multiple transcript variants.
NUB1, NYREN18, NEDD8 ultimate buster 1, Negative regulator of ubiquitin-like proteins 1, Renal carcinoma antigen NY-REN-18
Human: Q9Y5A7, Mouse: P54729
Human: 51667, Mouse: 53312