PEG10 Monoclonal Antibody

Categories: ,

Prices are excluding VAT and shipping costs

Product information

Price

€240, €410

Size

50 µl/µg | 100 µl/µg

Short name

Retrotransposon-derived protein PEG10

Host

Mouse

Isotype

IgG

Target protein

PEG10

Reactivity

Human

Immunogen

Purified recombinant fragment of human PEG10 expressed in E. Coli.

Purification

Affinity purification

Formulation

Ascitic fluid containing 0.03% sodium azide;0.5% BSA; 50%glycerol.

Storage

-20°C for 1 year

Product code

MB-AM10135

Additional information

This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1| and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis.
PEG10, EDR, KIAA1051, MAR2, MART2, MEF3L1, RGAG3, Retrotransposon-derived protein PEG10, Embryonal carcinoma differentiation-regulated protein, Mammalian retrotransposon-derived protein 2, Myelin expression factor 3-like protein 1, MEF3-lik
Human: Q86TG7, Mouse: Q7TN75
Human: 23089