PERK Polyclonal Antibody
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Product information
| Price | €175, €275, €395 |
|---|---|
| Size | 20 µl/µg | 50 µl/µg | 100 µl/µg |
| Short name | PERK Antibody |
| Host | Rabbit |
| Isotype | IgG |
| Target protein | EIF2AK3 |
| Recommended applications | ELISA, IF, IHC-p, WB |
| Reactivity | Human |
| Immunogen | The antiserum was produced against synthesized peptide derived from human E2AK3. AA range:61-110 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Formulation | Liquid in PBS containing 50% glycerol; 0.5% BSA and 0.02% sodium azide. |
| Storage | -20°C for 1 year |
| Product code | MB-AP14650 |
Additional information
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Eukaryotic translation initiation factor 2 alpha kinase 3 encoded by EIF2AK3 phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Eukaryotic translation initiation factor 2 alpha kinase 3 is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in EIF2AK3 are associated with Wolcott-Rallison syndrome.
EIF2AK3, PEK, PERK, Eukaryotic translation initiation factor 2-alpha kinase 3, PRKR-like endoplasmic reticulum kinase, Pancreatic eIF2-alpha kinase, HsPEK
Human: Q9NZJ5, Mouse: Q9Z2B5, Rat: Q9Z1Z1
Human: 9451, Rat: 29702