phospho-MLKL (S358) mouse Monoclonal Antibody(6F8)
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Product information
| Price | €175, €275, €395 |
|---|---|
| Size | 20 µl/µg | 50 µl/µg | 100 µl/µg |
| Short name | MLKL |
| Host | Mouse |
| Isotype | IgG |
| Target protein | MLKL |
| Recommended applications | ICC, IF, IHC-p |
| Reactivity | Human |
| Immunogen | Synthetic Peptide of phospho-MLKL (S358) |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Formulation | Liquid in PBS containing 50% glycerol; 0.5% BSA and 0.02% sodium azide. |
| Storage | -20°C for 1 year |
| Product code | MB-AM10129 |
Additional information
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This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain| however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.
MLKL
Human: Q8NB16, Mouse: Q9D2Y4
Human: 197259