PRMT6 Monoclonal Antibody
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Product information
| Price | €240, €410 |
|---|---|
| Size | 50 µl/µg | 100 µl/µg |
| Short name | Protein arginine N-methyltransferase 6 |
| Host | Mouse |
| Isotype | IgG |
| Target protein | PRMT6 |
| Recommended applications | ICC, IF, IHC-p, WB |
| Reactivity | Human, Mouse, Rat |
| Immunogen | Purified recombinant human PRMT6 protein fragments expressed in E.coli. |
| Purification | Affinity purification |
| Formulation | Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4; 150 mM NaCl) with 0.2% sodium azide; 50% glycerol. |
| Storage | -20°C for 1 year |
| Product code | MB-AM10111 |
Additional information
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The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity.
PRMT6, HRMT1L6, Protein arginine N-methyltransferase 6, Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6, Histone-arginine N-methyltransferase PRMT6
Human: Q96LA8, Mouse: Q6NZB1
Human: 55170, Mouse: 99890