Rb(Phospho Ser612) Polyclonal Antibody
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Product information
| Price | €175, €275, €395 |
|---|---|
| Size | 20 µl/µg | 50 µl/µg | 100 µl/µg |
| Short name | Retinoblastoma-associated protein |
| Host | Rabbit |
| Isotype | IgG |
| Target protein | RB1 |
| Recommended applications | ELISA, IF, IHC-p |
| Reactivity | Human, Mouse, Rat |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human Rb (phospho Ser612) |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Formulation | Liquid in PBS containing 50% glycerol; 0.5% BSA and 0.02% sodium azide. |
| Storage | -20°C for 1 year |
| Product code | MB-AP12234 |
Additional information
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The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Retinoblastoma-associated protein, RB1, Retinoblastoma-associated protein, p105-Rb, pRb, Rb, pp110
Human: P06400, Mouse: P13405
Human: 5925