ZAP-70(Phospho Tyr315) Polyclonal Antibody
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Product information
| Price | €175, €275, €395 |
|---|---|
| Size | 20 µl/µg | 50 µl/µg | 100 µl/µg |
| Short name | Tyrosine-protein kinase ZAP-70 |
| Host | Rabbit |
| Isotype | IgG |
| Target protein | ZAP70 |
| Recommended applications | ELISA, IF, IHC-p, WB |
| Reactivity | Human, Mouse |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ZAP-70 around the phosphorylation site of Tyr315. AA range:281-330 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Formulation | Liquid in PBS containing 50% glycerol; 0.5% BSA and 0.02% sodium azide. |
| Storage | -20°C for 1 year |
| Product code | MB-AP13289 |
Additional information
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This gene encodes an enzyme belonging to the protein tyrosine kinase family| and it plays a role in T-cell development and lymphocyte activation. This enzyme| which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation| functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases| Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect| a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
Tyrosine-protein kinase ZAP-70, ZAP70, SRK, Tyrosine-protein kinase ZAP-70, 70 kDa zeta-chain associated protein, Syk-related tyrosine kinase
Human: P43403, Mouse: P43404
Human: 7535, Mouse: 22637